mieloma multiplo: belantamab mafodotin (BLENREP) ottiene autorizzazione da EMA

Blenrep is indicated as monotherapy for the treatment of multiple myeloma in adult patients, who have received at least four prior therapies and whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy.

The active substance in Blenrep, belantamab mafodotin, consists of a monoclonal antibody (a type of protein) attached to a cytotoxic (cell-killing) molecule. The antibody has been designed to attach to a protein called B-cell maturation antigen (BCMA), which is present on the surface of abnormal immature plasma cells (myeloma cells). When Blenrep is given to the patient, the medicine’s antibody portion attaches to BCMA on the myeloma cells and delivers the cytotoxic molecule into the cells. Once inside, the cytotoxic molecule kills the cells by interfering with their ability to divide and grow. Blenrep also stimulates the immune system (the body’s natural defences) to attack the myeloma cells, and these actions combined are expected to slow down progression of the disease.

fonte: EMA website